About
I am a developmental geneticist focusing on developing rodent models of human prostate diseases.
Research interests
prostate cancer
chronic prostatitis/chronic pelvic pain syndrome
benign prostatic hyperplasia
synthetic DNA
Teaching interests
Genetics
Cancer Biology
Education
- Other, Developmental Genetics — Yale University (1990)
- Ph D, Genetics — John Hopkins University (1987)
- BS, Biology — University of Tampa (1982)
Publications
- Nanoparticle Redistribution in PC3 Tumors Induced by Local Heating in Magnetic Nanoparticle Hyperthermia: In Vivo Experimental Study. 2019
- Feasibility of Visualization and Analyses of Deposition of Newly Developed Dendritic Ligand-Coated Gold Nanoparticles in PC3 Tumors Using MicroCT Scan 2018
- Nanoparticle Redistribution in PC3 Tumors Induced by Local Heating in Magnetic Nanoparticle Hyperthermia. 2018
- IMAGING-ASSISTED INDIVIDUAL DESIGNS OF HEATING PROTOCOLS FOR PROSTATIC TUMORS IN MAGNETIC NANOPARTICLE HYPERTHERMIA, 2017
- Treatment efficacy for validating microCT based theoretical simulation approach in magnetic nanoparticle hyperthermia for cancer treatment 2017
- Quantifying Kinase-Specific Phosphorylation Stoichiometry Using Stable Isotope Labeling In a Reverse In-Gel Kinase Assay 2016
- Validation of Image-assisted Modeling Approach to Design Heating Protocols in Magnetic Nanoparticle Hyperthermia. 2016
- Identification of Infusion Strategy for Achieving Repeatable Nanoparticle Distribution and Quantifiable Thermal Dosage in Magnetic Nanoparticle Hyperthermia. , 2016
- A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. 2014
- Protein kinase A regulates MYC protein through transcriptional and post-translational mechanisms in a catalytic subunit isoform-specific manner 2013
Presentations
- Study of stability, toxicity and cellular localization of dendronized gold nanoparticles for in vivo (MCF-7) and in vivo xenograft (PC-3) mice models 2018
- Imaging-assisted individual designs of heating protocols for prostatic tumors in magnetic nanoparticle hyperthermia 2017
Grants and Contracts
- Using Stealth Nanocarriers with Mild Whole-body Hyperthermia to Enhance Co-delivery of Multiple Chemotherapeutics in Prostate Tumors 2026
- Collaborative Research: Physics-driven stochastic modeling for tumor structure inversion from in vivo experimental data 2019
- Mild hyperthermia to enhance delivery of therapeutic nanocarriers in tumors: imaging, in vivo study, and simulation 2017
Patents and Intellectual Property
- A method to produce supercoiled circular DNA in vitro. 2023
- PIM KINASE INHIBITORS IN COMBINATION WITH RNA SPLICING MODULATORS/INHIBITORS FOR TREATMENT OF CANCERS 2017